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Recombinant Human FGF-8a
Catalog Number:
100-25A
Synonyms:
Fibroblast Growth Factor-8, FGF-8a, AIGF, HBGF-8
Description:
FGF-8 is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. The human and murine FGF-8a and FGF-8b are identical, unlike human and mouse FGF-8e and FGF-8f, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors.CHO cell-derived Recombinant Human FGF-8a is a 21.2 kDa protein consisting of 182 amino acid residues.
AA Sequence:
QHVREQSLVT DQLSRRLIRT YQLYSRTSGK HVQVLANKRI NAMAEDGDPF AKLIVETDTF GSRVRVRGAE TGLYICMNKK GKLIAKSNGK GKDCVFTEIV LENNYTALQN AKYEGWYMAF TRKGRPRKGS KTRQHQREVH FMKRLPRGHH TTEQSLRFEF LNYPPFTRSL RGSQRTWAPE PR
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by a cell proliferation assay using balb/c 3T3 cells.
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Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
Bone, Skeletal, Cartilage
        
        

            

            
Cancer
            

            
FGF Superfamily
        
        

            

            
Proliferation
            

            
Stem Cells & Differentiation
        
    


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Country of Origin:
USA