Recombinant Human PDGF-AB
產品名稱： Recombinant Human PDGF-AB
英文名稱： Recombinant Human PDGF-AB
產品編號： 100-00AB
產品價格： 0
產品產地： USA
品牌商標： PEPROTECH
更新時間： null
使用范圍： null
上海研卉生物科技有限公司
- 聯系人 :
- 地址 : 上海市嘉定區葉城路1288號
- 郵編 :
- 所在區域 : 上海
- 電話 : 187****6455 點擊查看
- 傳真 : 點擊查看
- 郵箱 : yanhuibio@163.com
產品編號:
100-00AB
別名:
Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF
描述:
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).
氨基酸序列:
alpha chain MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT
beta chain MSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIGIVR KKPIFKKATV TLGDHLACKC ETVAAARPVT
來源:
E.coli
純度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
?
?
?
?
交叉反應:
Monkey, Mouse