NTRK1 polyclonal antibody
產(chǎn)品名稱： NTRK1 polyclonal antibody
英文名稱： NTRK1 polyclonal antibody
產(chǎn)品編號： PAB3398
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺灣臺北市內(nèi)湖區(qū)洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NTRK1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NTRK1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.
Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH.Cell. 1998 Sep 18;94(6):829-39.
- 2.
- A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.
Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV.J Biol Chem. 1997 Feb 28;272(9):5861-70.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of NTRK1 polyclonal antibody (Cat # PAB3398) in mouse brain lysate. NTRK1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Western Blot (Transfected lysate)
- Western blot analysis of TRKA (arrow) using rabbit NTRK1 polyclonal antibody (Cat # PAB3398). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NTRK1 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with NTRK1 polyclonal antibody (Cat # PAB3398) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 4914
- Protein Accession#:
- P04629
- Gene Name:
- NTRK1
- Gene Alias:
- DKFZp781I14186,MTC,TRK,TRK1,TRKA,p140-TrkA
- Gene Description:
- neurotrophic tyrosine kinase, receptor, type 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
- Other Designations:
- OTTHUMP00000038736,Oncogene TRK,high affinity nerve growth factor receptor,tyrosine kinase receptor A
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Asperger Syndrome
- Autistic Disorder
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Eating Disorders
- Edema
- Genetic Predisposition to Disease
- Hereditary Sensory and Autonomic Neuropathies
- Hyperparathyroidism, Secondary
- Kidney Failure, Chronic
- Leukemia, Myeloid, Acute
- Mental Disorders
- Neuroblastoma
- Social Perception
- Thyroid Diseases
- Thyroid Neoplasms