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Murine & Rat Growth Factors & Cytokines
Recombinant Murine TRAIL





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		Synonyms :
TNF-related apoptosis-inducing Ligand, TNFSF10, TL2



		Description :
TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells.  TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5.  These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery.  Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.



		Catalog #:
315-19



		Source :
E.coli



		Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Assay#1:Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml.



Assay#2:Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40.0-60.0 ng/ml.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN 



		PubMed Link :
TRAIL


Country of Origin :
USA
















        Size A
10μg
$80?
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        Size B
50μg
$195?
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        Size C
1mg
$1500?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.