Size??100ug
Cat code??200537
Species Cross-reactivity??R
Key Application??WB,ICC
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??IgG1
Molecular Weight??42kDa
Sensitivity??This antibody detects endogenous levels AMACR(C-terminus) and does not cross-react with related proteins.
Immunogen??Purified recombinant human AMACR(C-terminus) protein fragments expressed in E.coli.
UniProt Number??Q9UHK6
GeneBank ID??NM_014324
Subcellular location??Peroxisome. Mitochondrion
Formulation??Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername??RM; RACE; CBAS4; AMACRD
Gene_symbol??RM; RACE; CBAS4; AMACRD
Summary??This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)-and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
UniPort summary  Function??Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers
Application Images :??
Western blot detection of AMACR(C-terminus) antibody in Rat Liver lysates using AMACR(C-terminus) antibody (1:1000 diluted).
Predicted band size: 42KDa
Observed band size: 42KDa.