HMG-CoA reductase (pSer871) 抗體
產品名稱： HMG-CoA reductase (pSer871) 抗體
英文名稱： HMG-CoA reductase (pSer871) antibody
產品編號： PR-1030P
產品價格： null
產品產地： 江蘇
品牌商標： Hopebiot
更新時間： null
使用范圍： WB,IHC,ELISA,ICC,IP
- 聯系人 : 吳方
- 地址 : 江蘇省丹陽市呂城工業園
- 郵編 : 212300
- 所在區域 : 江蘇省
- 電話 : 189****1025 點擊查看
- 傳真 : 點擊查看
- 郵箱 : hopebiotech@163.com
Background:? HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Clarke and Hardie identified Ser871 of HMG CoA reductase as a substrate of AMP-activated kinase. The residue is highly conserved in rodents and man.
Description: Rabbit polyclonal to HMG-CoA reductase (pSer871)
Immunogen: A synthesized phosphopeptide derived from HMG-CoA reductase around the phosphorylation site of serine (N-R-SP-K-I).
Specificity: ?·Reacts with Human, Mouse, Hamster and Rat.???
·Isotype: IgG
Application:? ·Western blotting: 1/500-1000. Predicted Mol wt: 97 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
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