Active牛TNF alpha全長蛋白質
產品名稱： Active牛TNF alpha全長蛋白質
英文名稱： APC1 APC1 protein Cachectin DIF Differentiation inducing factor Macrophage cytotoxic factor Tnf TNF alpha TNF superfamily, member 2 TNF, mac
產品編號： ab87904
產品價格： 0
產品產地： 英國
品牌商標： abcam
更新時間： null
使用范圍： null
深圳市宇德立生物科技有限公司
- 聯系人 :
- 地址 : 深圳市寶安區西鄉寶民二路賢基大廈4E
- 郵編 :
- 所在區域 : 廣東
- 電話 : 133****4454 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 1484332550@qq.com
- 性質Recombinant
- 來源Yeast
- 氨基酸序列
- 種屬Cow
- 序列LRSSSQASSN KPVAHVVADI NSPGQLRWWD SYANALMANG VKLEDNQLVV PADGLYLIYS QVLFRGQGCP STPLFLTHTI SRIAVSYQTK VNILSAIKSP CHRETPEWAE AKPWYEPIYQ GGVFQLEKGD RLSAEINLPD YLDYAESGQV YFGIIAL
技術指標
Our?Abpromise guarantee?covers the use of?ab87904?in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 生物活性The biological activity of recombinant bovine TNF alpha was measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells. The ED50?for this effect is typically 5 8 ng/ml.
- 應用
Functional Studies
SDS-PAGE
- 形式Lyophilised
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濃度由溶解方法決定?
制備和貯存
- 穩定性和存儲
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 10% Trehalose, 1X PBSThis product is an active protein and may elicit a biological response in vivo, handle with caution.
- 復溶Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
常規信息
-
別名
- APC1
- APC1 protein
- Cachectin
see all - 功能Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
- 疾病相關Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
- 序列相似性Belongs to the tumor necrosis factor family.
- 翻譯后修飾The soluble form derives from the membrane form by proteolytic processing.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. - 細胞定位Secreted and Cell membrane.
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