鯉魚活性生長素 全長蛋白質
產品名稱： 鯉魚活性生長素 全長蛋白質
英文名稱： gH GH-N GH1 GHN Growth hormone Growth hormone 1 Growth hormone, normal Growth hormone, pituitary HG1 hGH-N IGHD1B Pituitary growth hormone R
產品編號： ab68389
產品價格： 0
產品產地： 英國
品牌商標： abcam
更新時間： null
使用范圍： null
深圳市宇德立生物科技有限公司
- 聯系人 :
- 地址 : 深圳市寶安區西鄉寶民二路賢基大廈4E
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- 所在區域 : 廣東
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- 性質Recombinant
- 來源E. coli
- 氨基酸序列
- 種屬Carp
- 序列The sequence of the first five N-terminal amino acids was determined and found to be Ser-Asp-Asn-Gln-Arg.
技術指標
Our?Abpromise guarantee?covers the use of?ab68389?in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 生物活性ab68389 is biologically active in rat 3T3 F442A preadipocytes, though its activity is 15-fold lower compared to bovine GH, but it is equally potent in vivo in promoting carp growth (Fine et al.1993).
- 應用
Functional Studies
SDS-PAGE
- 純度> 95 % by SDS-PAGE.
ab68389 is purified by proprietary chromatographic techniques. Purity is greater than 95.0% as determined by analysis by RP-HPLC and SDS-PAGE.?
- 形式Lyophilised
-
濃度由溶解方法決定?
制備和貯存
- 穩定性和存儲
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: None
Constituents: 0.3% Sodium bicarbonate, pH 8This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 復溶Reconstitute in sterile 18 MOhms/cm water to not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
常規信息
-
別名
- gH
- GH-N
- GH1
see all - 功能Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
- 疾病相關Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. - 序列相似性Belongs to the somatotropin/prolactin family.
- 細胞定位Secreted.