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EMD 66684

CAS No. : 1216884-39-7

MCE 國際站：EMD 66684

產(chǎn)品活性：EMD 66684 是 II 型血管緊張素 (AT1) 受體的拮抗劑。EMD 66684 對 AT1 亞型 Ang II 受體具有強(qiáng)親和力，IC₅₀ 為 0.7 nM。EMD 66684 也是一種抗缺血的細(xì)胞保護(hù)劑。

研究領(lǐng)域：GPCR/G Protein

作用靶點(diǎn)：Angiotensin Receptor

In Vitro: Ang II is known to activate at least two receptor subtypes, namely, AT1 and AT2 receptors.
EMD 66684 (0.1 μM) decreases Ang II (0.1 mM)-induced in basal and NS-induced NPY overflow, attenuates the NS-induced stimulation of both NE and NPY release.
EMD 66684 (0.01 nM-1 μM; 0, 30, 60 min) exhibits a time-dependent inhibition against Ang II in DMR (dynamic mass redistribution) responses, with IC₅₀s of 181.97 nM (0 min), 0.22 nM (30 min), 0.17 nM (60 min), respectively.
EMD 66684 exhibits binding affinities for the AT1 subtype Ang II receptor with an IC₅₀ value of 0.7 nM in rat adrenal cortical membranes, and inhibits Ang II-Induced contraction in rabbit aortic rings with an IC₅₀ value of 0.2 nM.

In Vivo: EMD 66684 (0.1, 0.3, 1 mg/kg; i.v.; once) results in a long lasting fall in blood pressure.
EMD 66684 (0.1 μM; 45 min) decreases the NS-induced overflow of NE and NPY from preparations from SHRs at 10-12 weeks old.

相關(guān)產(chǎn)品：Angiotensin II human??|??Losartan??|??Telmisartan??|??Tranilast??|??Valsartan??|??A 779??|??Buloxibutid??|??AVE 0991??|??Candesartan??|??Irbesartan??|??Nitrosoglutathione??|??YS-49??|??Olmesartan??|??Olodanrigan??|??PD 123319 ditrifluoroacetate??|??Sparsentan??|??Alamandine??|??Azilsartan medoxomil??|??Angiotensin III, human, mouse??|??CGP-42112??|??TRV-120027??|??Angiotensin II 5-valine

熱門產(chǎn)品線：重組蛋白? |? 藥物篩選? |? 天然產(chǎn)物? |? 熒光染料? |? PROTAC? |? 同位素標(biāo)記物

Trending products：Recombinant Proteins? |? Bioactive Screening Libraries? |? Natural Products? |? Dye Reagents? |? PROTAC? |? Isotope-Labeled Compounds

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