EMD 66684 | MedChemExpress (MCE)
產(chǎn)品名稱: EMD 66684 | MedChemExpress (MCE)
英文名稱: EMD 66684
產(chǎn)品編號: HY-103247
產(chǎn)品價格: 0
產(chǎn)品產(chǎn)地: 美國
品牌商標(biāo): MedChemExpress (MCE)
更新時間: 2024-07-30T10:46:17
使用范圍: null
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EMD 66684
CAS No. : 1216884-39-7
MCE 國際站:EMD 66684
產(chǎn)品活性:EMD 66684 是 II 型血管緊張素 (AT1) 受體的拮抗劑。EMD 66684 對 AT1 亞型 Ang II 受體具有強(qiáng)親和力,IC50 為 0.7 nM。EMD 66684 也是一種抗缺血的細(xì)胞保護(hù)劑。
研究領(lǐng)域:GPCR/G Protein
作用靶點(diǎn):Angiotensin Receptor
In Vitro: Ang II is known to activate at least two receptor subtypes, namely, AT1 and AT2 receptors.
EMD 66684 (0.1 μM) decreases Ang II (0.1 mM)-induced in basal and NS-induced NPY overflow, attenuates the NS-induced stimulation of both NE and NPY release.
EMD 66684 (0.01 nM-1 μM; 0, 30, 60 min) exhibits a time-dependent inhibition against Ang II in DMR (dynamic mass redistribution) responses, with IC50s of 181.97 nM (0 min), 0.22 nM (30 min), 0.17 nM (60 min), respectively.
EMD 66684 exhibits binding affinities for the AT1 subtype Ang II receptor with an IC50 value of 0.7 nM in rat adrenal cortical membranes, and inhibits Ang II-Induced contraction in rabbit aortic rings with an IC50 value of 0.2 nM.
In Vivo: EMD 66684 (0.1, 0.3, 1 mg/kg; i.v.; once) results in a long lasting fall in blood pressure.
EMD 66684 (0.1 μM; 45 min) decreases the NS-induced overflow of NE and NPY from preparations from SHRs at 10-12 weeks old.
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