?
            
            

            
Animal Free Cytokines
            
Recombinant Human PDGF-BB
            

            

            ?
        
        

            
?
            

            

                

                    

                        

                        
Synonyms :
                        
                        

                        
Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)
                        
                    
                    

                        

                        
Description :
                        
                        

                        
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). Manufactured using all non-animal reagents.
                        
                    
                    

                        

                        
Catalog #:
                        
                        

                        
AF-100-14B
                        
                    
                    

                        

                        
Source :
                        
                        

                        
E.coli
                        
                    
                    

                        

                        
Purity :
                        
                        

                        
Greater than 98% by SDS-PAGE gel and HPLC analyses.
                        
                    
                    

                        

                        
Endotoxin Level :
                        
                        

                        
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
                        
                    
                    

                        

                        
Biological Activity :
                        
                        

                        
Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
                        
                    
                    

                        

                        
AA Sequence :
                        
                        

                        
SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT 
                        
                    
                    

                        

                        
PubMed Link :
                        
                        

                        
PDGF-BB
                        
                    
                    

                        

                        
Country of Origin :
                        
                        

                        
USA
                        
                    
                    

                        
?
                        

                        
                    
                    

                        

                        
?
                        
                        

                        

                        

                            

                                

                                    
Size B
                                    
10μg
                                    
$215?
                                    
?
                                
                                

                                    
?
                                
                                

                                    
Size C
                                    
1mg
                                    
$4300?
                                    
?
                                
                                

                                    
?
                                
                            
                        
                        

                        
                    
                    

                        

                        
?
                        
                        

                        
                    
                    

                        

                        
?
                        
                        

                        
Special Sizes: 

                        Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.
                        
                    
                    

                        

                        
?
                        
                        

                        
Usage:

                        For Research Use Only. Not for use in diagnostic or therapeutic procedures. 
                        
                    
                
            
            

            ?