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Human Growth Factors & Cytokines
Recombinant Human Myostatin





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		Synonyms :
GDF-8



		Description :
Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth.  This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase.  Suppression of myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes.  Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin.  Recombinant Human myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.



		Catalog #:
120-00



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS 



		PubMed Link :
Myostatin+OR+GDF-8


Country of Origin :
USA
















        Size A
2μg
$80?
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        Size B
10μg
$195?
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        Size C
1mg
$5200?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.