PeproTech大鼠抗小鼠CD62L (L-Selectin) APC
產(chǎn)品名稱(chēng)： PeproTech大鼠抗小鼠CD62L (L-Selectin) APC
英文名稱(chēng)： Anti-MouseCD62L (L-Selectin)APC
產(chǎn)品編號(hào)： 04712-80-25
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： USA
品牌商標(biāo)： peperotech(BioGems)
更新時(shí)間： null
使用范圍： 流式
美國(guó)PeproTech(派普泰克)公司中國(guó)代表處
- 聯(lián)系人 :
- 地址 :  江蘇省蘇州市工業(yè)園區(qū)星湖街218號(hào)A1北座4樓L03
- 郵編 : 215123
- 所在區(qū)域 : 江蘇
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- 郵箱 : peprotech.infochina@thermofisher.com
The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains. The weight of the CD62L molecules depend on their origin: 74 kDa (on lymphocytes) or 95 kDa (on neutrophils). In the Mouseorganism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils. The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins (MadCAM-1, GLYCAM-1, and CD 34). It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes.