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RBC Lysis Solution is designed for the optimal lysis of Erythrocytes (Red Blood Cells) and is thus ideal for the isolation of Leukocytes (White Blood Cells). As the majority of blood cells in the body are Erythrocytes, mature RBCs are non-nucleated and therefore possess no DNA. Nucleated RBCs whose presence in peripheral blood is an abnormal condition in the common mammalian species, have been discovered in? maternal circulation and provide a potential source for non-invasive prenatal diagnosis, although this solution may not effectively lyse these types of nRBCs.1? RBC Lysis Solution contains Ammonium Chloride, among other components, which lyses the RBCs with minimal effect to lymphocytes while concentrating the intact, nucleated Leukocytes with centrifugation which are important in Isolation of not only DNA but also RNA from blood for further applications. Other applications include not only single-cell suspensions of mouse hematopoietic tissues such as spleen but also Human Peripheral Blood (HPB).??

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?Biological Industries Red Blood Cells (RBC) Lysis Solution is intended for use in isolation of leukocytes from whole blood. The RBC Lysis Solution selectively lyses the erythrocytes leaving the leukocytes. The resulting white blood cells can be readily lysed and processed when isolating nucleic acid with BIs RNA and DNA isolation kits: EZ-RNA (Cat. no. 20-400-10), EZ-DNA (Cat. no. 20-600-50), or with any other method for nucleic acid isolation from whole blood.

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