產品發布日期：PeproTech 2012年9月


Recombinant Human LIF

Catalog Number:
AF-300-05
Synonyms:
Differentiation-stimulating?factor, D factor, Melanoma-derived LPL inhibitor (MLPLI)
Description:
LIF是一種多效性細胞因子，由多種類型的細胞，包括T細胞，骨髓單核細胞系，成纖維細胞，肝細胞，心臟和黑色素瘤等產生。LIF通過抑制自發分化來促進胚胎干細胞(ES細胞)的長期維持。LIF的其它活性包括刺激肝臟急性期蛋白的合成，促進膽堿能神經的分化，以及通過抑制脂肪細胞中脂蛋白脂酶的活性而抑制脂肪生成。人與小鼠的LIF間具有種屬交叉反應活性。重組人LIF是一個分子量為19.6 kDa的蛋白質，含有180個氨基酸殘基，其中包括3個二硫鍵。生產過程中的所有試劑均為非動物源性。
AA Sequence:
SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
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Research Interests:


    

        

            

            
Diabetes / Weight Regulation
            

            
Immune System
        
        

            

            
Lipid Metabolism
            

            
Proliferation
        
        

            

            
Stem Cells & Differentiation
            
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Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.