? 中文名稱?信號轉導和轉錄激活因子2重組兔單克隆抗體
?別? ? 名 signal transducers and activators of transduction2; Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF3; P113; signal transducer and activator of transcription 2 113kD; STAT113; STAT2_HUMAN; p113.? ?
?研究領域 細胞生物? 神經生物學??
?抗體來源 Rabbit
?克隆類型 Monoclonal
?克 隆 號 4B1
?交叉反應 (predicted: Human, )
?產品應用 WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:400-800 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
?分 子 量 97kDa
?細胞定位 細胞核 細胞漿?
?性? ? 狀 Liquid
?濃? ? 度 1mg/ml
?免 疫 原 Recombinant human STAT2 protein (1-100aa):?
?亞? ? 型 IgG
?純化方法 affinity purified by Protein A
?儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
?保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
?PubMed PubMed
?產品介紹 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Function:
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 an