人 促紅細(xì)胞生成素受體 & 細(xì)胞因子受體共同亞基 蛋白, Fc 標(biāo)簽&Fc 標(biāo)簽
產(chǎn)品名稱： 人 促紅細(xì)胞生成素受體 & 細(xì)胞因子受體共同亞基 蛋白, Fc 標(biāo)簽&Fc 標(biāo)簽
英文名稱： Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag
產(chǎn)品編號： ERR-H5255
產(chǎn)品價格： 30200
產(chǎn)品產(chǎn)地： 中國
品牌商標(biāo)： 北京百普賽斯生物科技股份有限公司
更新時間： 2025-09-19T18:06:11
使用范圍： null
| 規(guī)格 | 價格 |
| 1mg |
- 聯(lián)系人 : 團(tuán)子
- 地址 : 北京經(jīng)濟(jì)技術(shù)開發(fā)區(qū)宏達(dá)北路8號5號樓4層
- 郵編 : 100176
- 所在區(qū)域 : 北京
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Epo (Erythropoietin) is the primary regulator of erythropoiesis and is critical for tissue oxygenation under both steady-state conditions and after acute blood loss or hypoxia. The EPO R is the primary receptor that binds to and transmits the activation signal of the EPO cytokine.ERO R is a member of the type I cytokine receptor superfamily. It usually exists as a homodimer and expressed extensively in EPO-responsive BM erythroid progenitors (BFU-E and CFU-E). The interaction of EPO with EPO R at the level of proerythroid cells activates proliferation, increases survival and promotes cell-restricted lineage erythroid differentiation. EPO also binds to the heterodimeric complex EPO-R on non-erythroid tissues (brain, heart, retina, kidney and others). This heterodimeric complex consists of one chain of EPO-R and a ubiquitous colony-stimulating factor 2 receptor β-chain (CD131). This heterodimeric receptor has been called the tissue protective receptor (TPR) of EPO. Although the interaction of EPO with TPR does not initiate erythropoiesis, it signals biochemical cascades (activation of PI3K, MARK, STAT5 and others), leading to the protection of cells from apoptosis, degeneration and cytotoxicity in general.