FGFR1 (phospho Y653/654) polyclonal antibody
產品名稱： FGFR1 (phospho Y653/654) polyclonal antibody
英文名稱： FGFR1 (phospho Y653/654) polyclonal antibody
產品編號： PAB0471
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of FGFR1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y653/654 of human FGFR1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Glycated fibroblast growth factor-2 is quickly produced in vitro upon low-millimolar glucose treatment and detected in vivo in diabetic mice.
Facchiano F, D'Arcangelo D, Russo K, Fogliano V, Mennella C, Ragone R, Zambruno G, Carbone V, Ribatti D, Peschle C, Capogrossi MC, Facchiano A.Mol Endocrinol. 2006 Nov;20(11):2806-18. Epub 2006 Jul 13.
- Applications
- Western Blot (Tissue lysate)
- The FGFR1 (phospho Y653/654) polyclonal antibody (Cat # PAB0471) is used in Western blot to detect FGFR in mouse liver tissue lysate. FGFR (arrow) was detected using the purified polyclonal antibody.
- Western Blot (Transfected lysate)
- Western blot analysis of FGFR1 (arrow) using FGFR1 (phospho Y653/654) polyclonal antibody (Cat # PAB0471). 293 cell lysates (2 &mciro;g/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR gene (Lane 2).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with FGFR1 (phospho Y653/654) polyclonal antibody (Cat # PAB0471) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 2260
- Protein Accession#:
- NP_075598;P11362
- Gene Name:
- FGFR1
- Gene Alias:
- BFGFR,CD331,CEK,FGFBR,FLG,FLJ99988,FLT2,HBGFR,KAL2,N-SAM
- Gene Description:
- fibroblast growth factor receptor 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
- Other Designations:
- FMS-like tyrosine kinase 2,OTTHUMP00000190874,OTTHUMP00000190878,OTTHUMP00000190879,OTTHUMP00000190881,basic fibroblast growth factor receptor 1,fms-related tyrosine kinase 2,fms-related tyrosine kinase-2,heparin-binding growth factor receptor,hydroxyaryl
- Interactome
- Related Disease
- Abnormalities, Multiple
- Acrocephalosyndactylia
- Alzheimer Disease
- Alzheimer disease
- Amenorrhea
- Anodontia
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Cardiovascular Diseases
- Chromosome Aberrations
- Chromosome Disorders
- Cleft Lip
- Cleft Palate
- Craniofacial Dysostosis
- Craniosynostoses
- Diabetes Complications
- Fractures, Bone
- Genetic Diseases, Inborn