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Solasodine hydrochloride

CAS No. : 6106-33-8

MCE 國際站：Solasodine hydrochloride

產品活性：Solasodine (Purapuridine) hydrochloride 是一種存在于茄科植物中的甾體生物堿。Solaso??dine hydrochloride 通過抑制 p53-MDM2 復合物、p21Waf1/Cip1 和 Bcl-2 蛋白來誘導細胞凋亡 (apoptosis)。Solaso??dine hydrochloride 具有神經保護、抗真菌、降壓、抗癌、抗動脈粥樣硬化、抗雄激素和抗炎活性。

研究領域：Apoptosis??|??Metabolic Enzyme/Protease??|??Anti-infection

作用靶點：MDM-2/p53??|??E1/E2/E3 Enzyme??|??Fungal??|??Apoptosis

In Vitro: Solasodine (90 μM; 2 days) hydrochloride treatment displays significant sprouting in P19 cells. Solasodine hydrochloride induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine hydrochloride induces the differentiation of P19 cells, essentially towards the neuronal pathway.

In Vivo: Solasodine (25-100?mg/kg; intraperitoneal injection; once) hydrochloride treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine hydrochloride has anticonvulsant and CNS depressant activities.
Solasodine (375 μM; i.c.v.; for 2 weeks) hydrochloride treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine hydrochloride treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells.

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熱門產品線：重組蛋白? |? 藥物篩選? |? 天然產物? |? 熒光染料? |? PROTAC? |? 同位素標記物

Trending products：Recombinant Proteins? |? Bioactive Screening Libraries? |? Natural Products? |? Dye Reagents? |? PROTAC? |? Isotope-Labeled Compounds

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