Anti-IDH2 Rabbit Polyclonal Antibody-抗體-抗體-生物在線
武漢紐斯特生物技術有限公司
Anti-IDH2 Rabbit Polyclonal Antibody

Anti-IDH2 Rabbit Polyclonal Antibody

商家詢價

產品名稱： Anti-IDH2 Rabbit Polyclonal Antibody

英文名稱： Anti-IDH2 Rabbit Polyclonal Antibody

產品編號： 21278

產品價格： null

產品產地： 美國

品牌商標： NewEastBio

更新時間： null

使用范圍： ELISA, WB, IHC

武漢紐斯特生物技術有限公司
  • 聯系人 :
  • 地址 : 武漢市東湖新技術開發區光谷生物城B3-3棟2-3樓
  • 郵編 : 430074
  • 所在區域 : 湖北
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IDH2 [21278]
[100 μL]		 ?

Catalog Number:??21278
Gene Symbol:??IDH2
Description: ??Anti-IDH2 Rabbit Polyclonal Antibody
Background: ???Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations of Arg-132 in IDH to Cys, His, Leu or Ser abolish magnesium binding and the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
Immunogen: ??Recombinant protein of human IDH2 (full length).
Applications: ??ELISA, WB, IHC
Recommended Dilutions: ??
ELISA: 1:1000-1:5000?
WB: 1:1000-1:5000?
IHC: 1:50-1:500
Concentration: ???0.1mg/ml
Host: ??Rabbit
Format: ??Liquid
Clonality: ??Polyclonal
Isotype: ??
Purity: ??Purified from serum
Storage buffer:
Preservative:??no
Constituents:??PBS (without Mg2+?and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:??Anti-IDH2 antibody recognizes IDH2 of vertebrates.
Storage Conditions:??Store at -20°C. Avoid freeze / thaw cycles.
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Western blot:??
Western blot analysis of recombinant IDH2 protein. Purified His-tagged IDH2 protein (full length) (Cat. #10200) was blotted with anti-IDH2 rabbit polyclonal antibody (Cat. # 21278).
Publications:
1.??Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
????Brain Tumor Pathology. January 2015, Volume 32, Issue 1, pp 3-11
2.??Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
????Nature 513, 110–114 (04 September 2014)
3.??Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism
????Journal of Neurochemistry. Volume 132, Issue 2, pages 183–193, January 2015

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