OSM (227aa), Human
產(chǎn)品名稱： OSM (227aa), Human
英文名稱：
產(chǎn)品編號： CB055-2401
產(chǎn)品價格： 0
產(chǎn)品產(chǎn)地： 美國
品牌商標(biāo)： ExCell Bio
更新時間： null
使用范圍： null
上海吉泰依科賽生物科技有限公司
- 聯(lián)系人 :
- 地址 : 上海市徐匯區(qū)桂平路481號18號樓5層
- 郵編 : 200233
- 所在區(qū)域 : 上海
- 電話 : 021-6439-8855 點擊查看
- 傳真 : 點擊查看
- 郵箱 : marketing@excellbio.com
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, including IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and share a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor β or LIF Receptor β to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. On the other hand, OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells.
Recombinant human Oncostatin M (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 228 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 25.9 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at ExCell Bio.