Phospho-PDGFRB-Y771 Rabbit pAb (AMR01229N)
產(chǎn)品名稱： Phospho-PDGFRB-Y771 Rabbit pAb (AMR01229N)
英文名稱： Phospho-PDGFRB-Y771 Rabbit pAb (AMR01229N)
產(chǎn)品編號(hào)： AMR01229N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍：
生物谷
- 聯(lián)系人 : 請(qǐng)聯(lián)系郵箱
- 地址 : 上海市徐匯區(qū)光啟城辦公樓3樓
- 郵編 : 100176
- 所在區(qū)域 : 上海
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分子量：Calculated MW: 124kDa Observed MW: 190kDa 細(xì)胞定位：Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein 稀釋方法：WB 1:500 - 1:2000 總結(jié)：The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.