?


Human Growth Factors & Cytokines
Recombinant Human TNF-β





?





		Synonyms :
Tumor Necrosis Factor-beta, TNFSF1, Lymphotoxin-alpha (LT-alpha)



		Description :
TNF-β is a potent mediator of inflammatory and immune responses.  It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2.  TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha.  Like TNF-α, TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission.  TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface.  TNF-β is cytotoxic to a wide range of tumor cells.  Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.



		Catalog #:
300-01B



		Source :
E.coli



		Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin-D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL 



		PubMed Link :
TNFbeta+AND+human


Country of Origin :
USA
















        Size A
5μg
$80?
?


?



        Size B
20μg
$195?
?


?



        Size C
1mg
$3000?
?


?















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.