Recombinant Biotinylated Cynomolgus ALPI Protein,His-Avi Tag
產(chǎn)品名稱： Recombinant Biotinylated Cynomolgus ALPI Protein,His-Avi Tag
英文名稱： Recombinant Biotinylated Cynomolgus ALPI Protein,His-Avi Tag
產(chǎn)品編號： 93065ES
產(chǎn)品價格： 詢價
產(chǎn)品產(chǎn)地： Yeasen
品牌商標： Yeasen
更新時間： 2025-08-21T09:01:23
使用范圍： null
翌圣生物科技（上海）股份有限公司
- 聯(lián)系人 : 李自轉
- 地址 : 上海市浦東新區(qū)天雄路166弄一號樓三層南單元
- 郵編 : 200030
- 所在區(qū)域 : 上海
- 電話 : 139****5640 點擊查看
- 傳真 : 點擊查看
- 郵箱 : lizizhuan@yeasen.com
- 二維碼 : 點擊查看
產(chǎn)品介紹
Intestinal alkaline phosphatase (ALPI) is an enzyme primarily encoded by the ALPI gene in the human body. This enzyme is mainly present in the small intestine and the liver, and can also be found in other tissues, although in smaller amounts. The main function of intestinal alkaline phosphatase in the small intestine is to assist in the digestion and absorption of phosphates and fats from food. Additionally, it is used as one of the clinical diagnostic markers for detecting intestinal diseases or bone disorders. Research on ALPI in human diseases also suggests that it may play a role in certain intestinal diseases and inflammatory processes. The gene responsible for IAP is mapped on the long arm of chromosome 2. IAP is a heat stable isozyme and more active at pH 9.7. Unlike other AP’s the side chain of IAP lacks terminal sialic acid residues. IAP is essential for lipids absorption and is involved in reducing inflammation. IAP suppresses inflammation, particularly by modifying the gut microflora and dephosphorylating LPS. Any alteration in IAP expression and activity increases the vulnerability to inflammation. Inflammatory bowel disease (IBD) is an indication of a condition where the patient’s endogenous IAP production and activity are reduced. Exogenous IAP injection may be a good option for treating IBD and other disorders caused by the disruption of gut microbiota.
產(chǎn)品性質
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產(chǎn)品別稱
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IAP
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種屬
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Cynomolgus
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表達序列
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Ile 20 - Asp 502
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Accession
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A0A2K5VFX3
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標簽
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C-His-Avi Tag
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表達系統(tǒng)
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HEK293
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分子量
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The protein has a predicted MW of 56.9 kDa
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純度
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> 95% as determined by SDS-PAGE
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內(nèi)毒素
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< 1.0 EU per μg by the LAL method.
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制劑
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Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
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外觀
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Liquid
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生物活性
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ELISA: Biotinylated Cynomolgus ALPI Protein; His-Avi Tag was immobilized at 1 μg/ml (100 μL/well) on streptavidin precoated. Increasing concentrations of Anti-His mIgG2a Antibody were added.
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產(chǎn)品特色
高純度、高活性、低內(nèi)毒素、高批間一致性
應用案例
SDS-PAGE
Figure 1.On SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Bioactivity-ELISA
Figure 2. Biotinylated Cynomolgus ALPI Protein; His-Avi Tag was immobilized at 1 μg/ml (100 μL/well) on streptavidin precoated. Increasing concentrations of Anti-His mIgG2a Antibody were added.
存儲條件
-85 ~ -65℃保存，收到貨之日起，6個月有效期。避免反復凍融，建議等分分裝為一次實驗使用量，分裝后，-80℃凍存。