Anti-TRAIL Polyclonal Antibody

英文名稱
Anti-TRAIL Polyclonal Antibody
別名
Apo-2L;APO2L;CD253;TL2;TNLG6A;
應用
WB
稀釋比例
WB 1:3000.
交叉反應
Human Mouse Rat
蛋白分子量
42kDa
Gene ID
8743
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG
免疫原
A synthetic peptide of human TRAIL
性狀
液體
Public Immunogen Range
A synthetic peptide of human TRAIL
Subcellular Locations
Cytoplasm
Swiss Prot
P50591
克隆類型
Polyclonal Antibody
背景資料
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.