PeproTech重組小鼠RANK Ligand 250ug-細胞/細菌培養-試劑-生物在線

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美國PeproTech(派普泰克)公司中國代表處
PeproTech重組小鼠RANK Ligand 250ug

PeproTech重組小鼠RANK Ligand 250ug

商家詢價

產品名稱： PeproTech重組小鼠RANK Ligand 250ug

英文名稱： Murine sRANK Ligand

產品編號： 315-11C

產品價格： 0

產品產地： 美國

品牌商標： PeproTech

更新時間： null

使用范圍： null

美國PeproTech(派普泰克)公司中國代表處
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  • 地址 :  江蘇省蘇州市工業園區星湖街218號A1北座4樓L03
  • 郵編 : 215123
  • 所在區域 : 江蘇
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  • 郵箱 : peprotech.infochina@thermofisher.com

Recombinant Murine sRANK Ligand

Catalog Number:
315-11C
Synonyms:
soluble Receptor Activator of NF-κB Ligand,?TNFSF11, TRANCE (TNF-Related Activation-induced Cytokine), OPGL, ODF (Osteoclast Differentiation Factor), CD254
Description:
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate na?ve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Murine sRANK Ligand is a 19.8 kDa polypeptide comprising the TNF-homologous region of RANKL (178 amino acid residues).
AA Sequence:
FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLSSWYH DRGWAKISNM TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPTDYLQLM VYVVKTSIKI PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SIQVSNPSLL DPDQDATYFG AFKVQDID
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to activate LacZ reporter under control of NF-kappa-B-responsive element in RAW264.7 cells in the absence of any cross-linking. The expected ED50?for this effect is 3.0-20.0 ng/ml.
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Research Interests:
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Country of Origin:
USA