Size??100ug
Cat code??200587
Species Cross-reactivity??H
Key Application??WB
Host??Mouse
Antibody type??Monoclonal antibody
Purified method??Affinity purified
Isotype??null
Molecular Weight??55kDa
Sensitivity??This antibody detects endogenous levels TAB1(N-terminus) and does not cross-react with related proteins.
Immunogen??Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.
UniProt Number??Q15750
GeneBank ID??NM_006116
Subcellular location??null
Formulation??Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername??3′-Tab1; MAP3K7IP1
Gene_symbol??3′-Tab1; MAP3K7IP1
Summary??The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is
known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and
WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this
protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a
dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta
receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14
(MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which
contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants
encoding distinct isoforms have been reported
UniPort summary  Function??May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis
Application Images :??
Western blot detection of TAB1(N-terminus) antibody in K562&Hela lysates using TAB1(N-terminus) antibody (1:1000 diluted).
Predicted band size: 55KDa
Observed band size: 55KDa.