Recombinant Human EGF-L7
Catalog Number:
100-61
Synonyms:
Epidermal growth factor-like protein 7, MEGF7, Multiple EGF-like domains, protein 7, NOTCH4-like protein, VE-statin, Zneu1
Description:
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EGF-L7（Epidermal Growth Factor Like Protein 7, Multiple EGF Like Domains Protein 7, VE Statin）是一個(gè)多結(jié)構(gòu)域蛋白，含有兩個(gè)EGF樣域和一個(gè)EMI域。EGF-L7幾乎完全是在內(nèi)皮細(xì)胞中表達(dá)，它的功能是促進(jìn)血管系統(tǒng)的正常發(fā)育，尤其是管腔化。EGF-L7能夠拮抗性結(jié)合Notch受體，從而抑制臍靜脈內(nèi)皮細(xì)胞(HUVEC)和神經(jīng)干細(xì)胞中Notch信號通路。在誘發(fā)的缺氧及后續(xù)的的復(fù)氧（H/ R）研究模型中，EGF-L7可以抑制細(xì)胞間黏附分子-1(ICAM-1)的表達(dá)并增強(qiáng)對NF-κB活性的抑制作用。此外，EGF-L7可以趨化內(nèi)皮細(xì)胞，并結(jié)合于細(xì)胞外基質(zhì)。EGF-L7的過度表達(dá)可以在多種癌癥中檢測到，并通常與轉(zhuǎn)移性增強(qiáng)和預(yù)后不良相關(guān)。重組人EGF-L7是一個(gè)分子量為28 kDa的蛋白，含有251個(gè)氨基酸殘基。
AA Sequence:
MYRPGRRVCA VRAHGDPVSE SFVQRVYQPF LTTCDGHRAC STYRTIYRTA YRRSPGLAPA RPRYACCPGW KRTSGLPGAC GAAICQPPCR NGGSCVQPGR CRCPAGWRGD TCQSDVDECS ARRGGCPQRC VNTAGSYWCQ CWEGHSLSAD GTLCVPKGGP PRVAPNPTGV DSAMKEEVQR LQSRVDLLEE KLQLVLAPLH SLASQALEHG LPDPGSLLVH SFQQLGRIDS LSEQISFLEE QLGSCSCKKD S
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Data Not Available.
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Research Interests:
Angiogenesis/ Cardiovascular
Cancer
Chemotaxis
Inflammation
Stem Cells & Differentiation
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Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.