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Product Description

LDN193189 (HCl) is a highly-potent inhibitor of BMP signaling, specifically blocking ALK1 (IC50?of 0.8 nM), ALK2 (IC50?of 0.8 nM), ALK3 (IC50of 5.3 nM), and ALK6 (IC50?of 16.7 nM), and in turn affecting Smad1/5/8 expression (Galvin-Burgess, et al.). LDN193189 (HCl) has been shown to contribute to the differentiation of pluripotent stem cells (PSCs) into functional pancreatic beta cells when combined with CHIR99021 (Cat. No. SM-0001-0010), SANT-1 (Cat. No. SM-0008-0010), Y27632 (Cat. No. SM-0013-0010), Compound E (Cat. No. SM-0002-0010), RepSox (Cat. No. SM-0006-0010), Triiodothyronine Salt (Cat. No. SM-0011-0500) along with other growth factors (Pagliuca, et al.). LDN193189 has also been utilized in the derivation of neural progenitor cells (Edri, et al.), and cortical neurons (Qi, et al.) from PSCs.?
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Product Synonyms:

LDN193189 tetrahydrochloride, LDN-193189, 1062368-62-0?

Constructed from renowned protocols, Biological Industries selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

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?產品官網鏈接：https://www.bioind.com/worldwide/ldn-193189/

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