人活性ATAD2蛋白片段 核信號轉導
產品名稱： 人活性ATAD2蛋白片段 核信號轉導
英文名稱： AAA nuclear coregulator cancer-associated protein AAA nuclear coregulator, cancer-associated ANCCA Atad2 ATAD2_HUMAN ATPase family AAA domai
產品編號： ab198131
產品價格： 0
產品產地： 英國
品牌商標： abcam
更新時間： null
使用范圍： null
- 聯系人 :
- 地址 : 深圳市寶安區西鄉寶民二路賢基大廈4E
- 郵編 :
- 所在區域 : 廣東
- 電話 : 133****4454 點擊查看
- 傳真 : 點擊查看
- 郵箱 : 1484332550@qq.com
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- 性質Recombinant
- 來源E. coli
- 氨基酸序列
- AccessionQ6PL18
- 種屬Human
- 序列MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLEVLFQGPLGSQEEDTFRELRIFLRNVTHR LAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDY LRDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQ LCEEIQESR
- 分子量42 kDa including tags
- 氨基酸981 to 1108
- 標簽GST tag N-Terminus
- 額外的序列信息Bromodomain; NM_014109.
技術指標
Our?Abpromise guarantee?covers the use of?ab198131?in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 生物活性
Assay was performed using an ATAD2 Inhibitor Screening Assay Kit.
- 應用
Functional Studies
SDS-PAGE
- 純度>= 95 % by SDS-PAGE.
- 形式Liquid
-
濃度100 μg 濃度為 2.67 mg/ml?
制備和貯存
- 穩定性和存儲
Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8
Constituents: 0.71% Tris HCl, 0.72% Sodium chloride, 0.02% Potassium chloride, 10% GlycerolThis product is an active protein and may elicit a biological response in vivo, handle with caution.
常規信息
-
別名
- AAA nuclear coregulator cancer-associated protein
- AAA nuclear coregulator, cancer-associated
- ANCCA
see all - 功能May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
- 組織特異性Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
- 序列相似性Belongs to the AAA ATPase family.
Contains 1 bromo domain. - 細胞定位Nucleus.
- Information by UniProt
Active human ATAD2 protein fragment 圖像
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Functional Studies - Active human ATAD2 protein fragment (ab198131)Activity assay using ab198131.
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SDS-PAGE - Active human ATAD2 protein fragment (ab198131)