PeproTech重組人sIL-4 Receptor α (CHO cell derived) 500ug
產品名稱： PeproTech重組人sIL-4 Receptor α (CHO cell derived) 500ug
英文名稱： Human sIL-4 Receptor α (CHO cell derived)
產品編號： 200-04RC
產品價格： 0
產品產地： 美國
品牌商標： PeproTech/派普泰克
更新時間： null
使用范圍： null
美國PeproTech(派普泰克)公司中國代表處
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- 地址 :  江蘇省蘇州市工業(yè)園區(qū)星湖街218號A1北座4樓L03
- 郵編 : 215123
- 所在區(qū)域 : 江蘇
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- 郵箱 : peprotech.infochina@thermofisher.com
Recombinant Human sIL-4 Receptor α (CHO cell derived)
Catalog Number:
200-04RC
Synonyms:
soluble Interleukin-4Rα, soluble IL-4 Receptor alpha, CD124
Description:
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc).? The type I receptor contains, in addition to the γc, an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα.? The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity.? It plays an important role in regulating the differentiation of na?ve CD4+ T cells and class switching to IgG1 and IgE.? PeproTechsCHO cell-derived Recombinant Human sIL-4 Receptor α is a 23.9 kDa glycoprotein corresponding to 209 amino acid residues of the extracellular domain of IL-4Rα. As a result of glycosylation, Recombinant Human sIL-4 Receptor α migrates with an apparent molecular mass of approximately 50-65 kDa by SDS-PAGE gel, under reducing conditions.
AA Sequence:
GNMKVLQEPT CVSDYMSIST CEWKMNGPTN CSTELRLLYQ LVFLLSEAHT CIPENNGGAG CVCHLLMDDV VSADNYTLDL WAGQQLLWKG SFKPSEHVKP RAPGNLTVHT NVSDTLLLTW SNPYPPDNYL YNHLTYAVNI WSENDPADFR IYNVTYLEPS LRIAASTLKS GISYRARVRA WAQCYNTTWS EWSPSTKWHN SYREPFEQH
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The?ED50?was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is ≤ 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of ≥ 2 x 105?units/mg.
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Research Interests:
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Apoptosis |  |
Cancer |
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Cell Culture |  |
Immune System |
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Inflammation |  |
Proliferation |
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Receptors |  |
Stem Cells & Differentiation |
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Allergy |  |
Transplantation |
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Country of Origin:
USA