ITGAM monoclonal antibody, clone ICRF44
產(chǎn)品名稱： ITGAM monoclonal antibody, clone ICRF44
英文名稱： ITGAM monoclonal antibody, clone ICRF44
產(chǎn)品編號： MAB5619
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 臺灣
品牌商標(biāo)： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺灣臺北市內(nèi)湖區(qū)洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native ITGAM.
- Immunogen:
- Native purified ITGAM from rheumatoid synovial cells and human monocytes.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- human CD11b/Mac-1a.
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In 100 mM BBS, pH 8.2
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- Flow Cytometry (1 ug/106 cells)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Overlapping, but not identical, sites are involved in the recognition of C3bi, neutrophil inhibitory factor, and adhesive ligands by the alphaMbeta2 integrin.
Zhang L, Plow EF.J Biol Chem. 1996 Jul 26;271(30):18211-6.
- 2.
- Integrins as promiscuous signal transduction devices.
Petty HR, Todd RF 3rd.Immunol Today. 1996 May;17(5):209-12.
- 3.
- Two conformations of the integrin A-domain (I-domain): a pathway for activation?
Lee JO, Bankston LA, Arnaout MA, Liddington RC.Structure. 1995 Dec 15;3(12):1333-40.
- Application Image
- Immunohistochemistry (Frozen sections)
- Flow Cytometry
- Entrez GeneID:
- 3684
- Gene Name:
- ITGAM
- Gene Alias:
- CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6
- Gene Description:
- integrin, alpha M (complement component 3 receptor 3 subunit)
- Omim ID:
- 120980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- antigen CD11b (p170),complement component receptor 3, alpha,integrin alpha M,macrophage antigen alpha polypeptide,neutrophil adherence receptor alpha-M subunit
- Related Disease
- Autoimmune Diseases
- Cardiovascular Diseases
- Crohn's disease
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Helicobacter Infections
- Lupus Erythematosus, Discoid
- Lupus Erythematosus, Systemic
- Lupus Nephritis
- Macular Degeneration
- Nephritis
- Stomach Ulcer