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Other Recombinant Proteins
Recombinant Human ApoE2





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		Synonyms :
Apolipoprotein E2



		Description :
ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism.  In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism.  Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ.  ApoE is an important constituent of all plasma lipoproteins.  It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism.  It also binds with the LDL receptor (apo B/E).  Defects in ApoE are a cause of hyperlipoproteinemia type III.  ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.  Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity.  E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels.  Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.



		Catalog #:
350-12



		Source :
E.coli



		Purity :
Greater than 90% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Data not available.



                AA Sequence :
MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKCL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH 



		PubMed Link :
ApoE2


Country of Origin :
USA
















        Size A
100μg
$80?
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        Size B
500μg
$195?
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        Size C
1mg
$350?
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Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.