Sunitinib 557795-19-4-常用生化試劑-試劑-生物在線

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北京百奧創(chuàng)新科技有限公司
Sunitinib 557795-19-4

Sunitinib 557795-19-4

商家詢價(jià)

產(chǎn)品名稱： Sunitinib 557795-19-4

英文名稱： Sunitinib

產(chǎn)品編號(hào)： 557795-19-4

產(chǎn)品價(jià)格： 0

產(chǎn)品產(chǎn)地： 國外

品牌商標(biāo)： MEDKOO

更新時(shí)間： null

使用范圍： null

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Description:?Sunitinib free base is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor. Sunitinib malate salt was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell apoptosis and thus results in tumor shrinkage. Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors.

Name: Sunitinib free base
CAS#: 557795-19-4 (free base)
Chemical Formula: C22H27FN4O2
Exact Mass: 398.2118
Molecular Weight: 398.48
Elemental Analysis: C, 66.31; H, 6.83; F, 4.77; N, 14.06; O, 8.03

Synonym:?SU11248; SU-11248; SU 11248; SU011248; sunitinib. US brand name: Sutent.

IUPAC/Chemical Name:?(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

InChi Key:?WINHZLLDWRZWRT-ATVHPVEESA-N

InChi Code:?InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

SMILES Code:?CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C2/C3=C(C=CC(=C3)F)NC2=O)C

Appearance:?Yellow solid powder

Purity:?>98% (or refer to the Certificate of Analysis)

Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:?Soluble in DMSO, not in water

Shelf Life:?>2 years if stored properly

Drug Formulation:?This drug may be formulated in DMSO

Stock Solution Storage:?0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:?2934.99.9001