CXCR2 monoclonal antibody, clone 19
產品名稱： CXCR2 monoclonal antibody, clone 19
英文名稱： CXCR2 monoclonal antibody, clone 19
產品編號： MAB1850
產品價格： null
產品產地： 臺灣
品牌商標： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of CXCR2.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1-19 of human CXCR2.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.2
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Expression and functional activity of the IL-8 receptor type CXCR1 and CXCR2 on human mast cells.
Lippert U, Artuc M, Grutzkau A, Moller A, Kenderessy-Szabo A, Schadendorf D, Norgauer J, Hartmann K, Schweitzer-Stenner R, Zuberbier T, Henz BM, Kruger-Krasagakes S.J Immunol. 1998 Sep 1;161(5):2600-8.
- 2.
- Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78.
Wuyts A, Proost P, Lenaerts JP, Ben-Baruch A, Van Damme J, Wang JM.Eur J Biochem. 1998 Jul 1;255(1):67-73.
- 3.
- Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2.
Wolf M, Delgado MB, Jones SA, Dewald B, Clark-Lewis I, Baggiolini M.Eur J Immunol. 1998 Jan;28(1):164-70.
- Applications
- Flow Cytometry
- Isolated human neutrophils were incubated with 1.0 ug CXCR2 monoclonal antibody, clone 19 (Cat # MAB1850) followed by staining with goat F (ab') 2 anti-mouse IgG FITC [ shaded peak ] . Specificity of signal was confirmed by staining the neutrophils with 1.0 ug mouse IgG1 isotype control followed by the secondary antibody [ unshaded peak ] . The data indicate that approximately 98% of the isolated neutrophil population stains positive for this CXCR2 (M2 region).
- Application Image
- Western Blot
- Immunohistochemistry
- Immunocytochemistry
- ELISA
- Inhibition Assay
- Flow Cytometry
- enlarge
- Entrez GeneID:
- 3579
- Gene Name:
- CXCR2
- Gene Alias:
- CD182,CDw128b,CMKAR2,IL8R2,IL8RA,IL8RB
- Gene Description:
- chemokine (C-X-C motif) receptor 2
- Omim ID:
- 146928
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
- Other Designations:
- C-X-C chemokine receptor type 2,CXC-R2,CXCR-2,CXCR2 gene for IL8 receptor type B,GRO/MGSA receptor,IL-8 receptor type 2,IL-8R B,chemokine (CXC) receptor 2,high affinity interleukin-8 receptor B,interleukin 8 receptor B,interleukin 8 receptor type 2,interl
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