Kv1.1, also known as potassium voltage-gated channel subfamily A member 1, is a shaker related voltage potassium
channel that in humans is encoded by the SCNA1 gene (3-5).
It is strongly expressed in a variety of neurons in adult
rodents, and it appears to be involved in regulating neuronal
excitability. Specifically it plays a role in several
developmental processes including proliferation, migration
and cell-cell adhesion (6). The Isaacs syndrome is a result of
an autoimmune reaction against the Kv1.1 ion channel (7).