人源 LDLR 蛋白|Human LDLR Protein, His Tag
產(chǎn)品名稱： 人源 LDLR 蛋白|Human LDLR Protein, His Tag
英文名稱： Human LDLR Protein, His Tag
產(chǎn)品編號(hào)： PME101199
產(chǎn)品價(jià)格： 0
產(chǎn)品產(chǎn)地： China
品牌商標(biāo)： DIMA Biotech
更新時(shí)間： null
使用范圍： null
締碼生物科技（武漢）有限公司
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The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]