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Recombinant Human FGF-21

Catalog Number:
AF-100-42
Synonyms:
Fibroblast Growth Factor-21, FGFL
Description:
FGF-21是一種分泌型生長因子,屬于FGF家族。這個家族的蛋白通過促進細胞的增殖和分化，在胎兒發(fā)育和產(chǎn)后生長，以及各種組織的再生過程中發(fā)揮著重要作用。FGF-21在輔助因子β-Klotho蛋白的存在下，通過FGFR1c和4受體進行信號傳導，刺激脂肪細胞攝取胰島素依賴的葡萄糖。重組人FGF-21是一個分子量為19.5 kDa的蛋白，由182個氨基酸殘基組成。生產(chǎn)過程中的所有試劑均為非動物源性。
AA Sequence:
MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS
Source:
E.coli
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected?ED50?for this effect is 0.3-0.6 μg/ml, in the presence of murine Klotho.
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Research Interests:


    

        

            

            
Angiogenesis/ Cardiovascular
            

            
FGF Superfamily
        
        

            

            
Proliferation
            
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Country of Origin:
USA