NFKBIA (phospho S32/36) polyclonal antibody
產(chǎn)品名稱： NFKBIA (phospho S32/36) polyclonal antibody
英文名稱： NFKBIA (phospho S32/36) polyclonal antibody
產(chǎn)品編號： PAB25387
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 臺灣
品牌商標(biāo)： Abnova
更新時間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺灣臺北市內(nèi)湖區(qū)洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺灣
- 電話 : +886-920**1152 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of NFKBIA.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding S32/36 of human NFKBIA.
- Sequence:
- H-D-Sp-G-L-D-Sp -M-K
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Affinity purification
- Storage Buffer:
- In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 4792
- Protein Accession#:
- P25963
- Gene Name:
- NFKBIA
- Gene Alias:
- IKBA,MAD-3,NFKBI
- Gene Description:
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
- Omim ID:
- 164008
- Gene Ontology:
- Hyperlink
- Gene Summary:
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
- Other Designations:
- IkappaBalpha,nuclear factor of kappa light chain gene enhancer in B-cells
- Gene Pathway
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Epithelial cell signaling in Helicobacter pylori infection
- Neurotrophin signaling pathway
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway
- Related Disease
- Adenocarcinoma
- Alcoholism
- Arthritis, Psoriatic
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Behcet Syndrome
- Breast cancer
- Breast Neoplasms
- Bronchiolitis, Viral
- Calcinosis
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Cardiovascular Diseases
- Carotid Stenosis
- Colorectal Neoplasms
- Connective Tissue Diseases
- Coronary Artery Disease