Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody;FITC conjugated
產(chǎn)品名稱： Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody;FITC conjugated
英文名稱：
產(chǎn)品編號： CSB-PA333180LC01HFD
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： CN
品牌商標(biāo)： CUSABIO
更新時(shí)間： null
使用范圍： ELISA.Not yet tested in other applications.
武漢華美生物工程有限公司
- 聯(lián)系人 :
- 地址 : 武漢東湖開發(fā)區(qū)高新大道818號高科醫(yī)療器械園B11號
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- 所在區(qū)域 : 湖北
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Uniprot ID:P26664 Species Reactivity:Hepatitis C virus genotype 1a Antibody type:Polyclonal Antibody Aliases:Capsid protein C,p21,gp32,gp35,NS1,gp68,gp70,p23,Hepacivirin,NS3P,p70,NS4A,NS4B,p27,NS5A,p56,NS5B,p68Raised in:Rabbit Background\Function :Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity). Stroage Buffer:Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Purity:Caprylic Acid Ammonium Sulfate Precipitation purified 武漢華美生物工程有限公司專營基因、蛋白、抗體、ELISA試劑盒、診斷試劑原料、藥物殘留、食品安全小分子及其他小分子等高質(zhì)量生物產(chǎn)品，我們的產(chǎn)品涉及血管生成、細(xì)胞凋亡/自噬、合成/代謝、血液凝固、細(xì)胞粘附、細(xì)胞周期、補(bǔ)體、發(fā)育蛋白、DNA損傷/DNA修復(fù)、細(xì)胞因子、藥物殘留與食品安全、受精作用、生長因子、神經(jīng)生物學(xué)、氧化應(yīng)激、信息受體、轉(zhuǎn)錄/轉(zhuǎn)錄調(diào)控、運(yùn)輸、泛素、信號傳導(dǎo)通路、自身免疫等多個(gè)研究領(lǐng)域，包括涵蓋37個(gè)種屬的多達(dá)萬種的ELISA試劑盒。詳細(xì)信息請登錄：www.cusabio.cn/