Anti-HSPA1A Polyclonal Antibody

英文名稱
Anti-MAP3K5 Polyclonal Antibody
宿主
Rabbit
別名
ASK1;MAPKKK5;MEKK5
應用
WB
稀釋比例
WB 1:500-1:2000.
交叉反應
Human Mouse
蛋白分子量
155kDa
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG
免疫原
Recombinant protein of human MAP3K5
Subcellular 
Locations
Cytoplasm Endoplasmic reticulum
Swiss Prot
Q99683
克隆類型
Polyclonal Antibody
背景資料
Mitogen-activated protein kinase (MAPK) signaling 
cascades include MAPK or extracellular signal-regulated 
kinase (ERK), MAPK kinase (MKK or MEK), and MAPK 
kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK 
phosphorylates and activates its downstream protein 
kinase, MAPK kinase/MEK, which in turn activates MAPK. 
The kinases of these signaling cascades are highly 
conserved, and homologs exist in yeast, Drosophila, and 
mammalian cells. MAPKKK5 contains 1,374 amino acids 
with all 11 kinase subdomains. Northern blot analysis 
shows that MAPKKK5 transcript is abundantly expressed 
in human heart and pancreas. The MAPKKK5 protein 
phosphorylates and activates MKK4 (aliases SERK1, 
MAPKK4) in vitro, and activates c-Jun N-terminal kinase 
(JNK)/stress-activated protein kinase (SAPK) during 
transient expression in COS and 293 cells; MAPKKK5 does 
not activate MAPK/ERK.