Pexidartinib 1029044-16-3
產品名稱： Pexidartinib 1029044-16-3
英文名稱： Pexidartinib
產品編號： 1029044-16-3
產品價格： 0
產品產地： 國外
品牌商標： MEDKOO
更新時間： null
使用范圍： null
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Description:?Pexidartinib, also know as PLX-3397, is a CSF1R inhibitor with IC50 of 20 nM in development by Plexxikon for the treatment of tenosynovial giant cell tumors. It is in a phase 3 clinical trial for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS).
CAS#: 1029044-16-3 (free base)
Chemical Formula: C20H15ClF3N5
Exact Mass: 417.09681
Molecular Weight: 417.81
Elemental Analysis: C, 57.49; H, 3.62; Cl, 8.49; F, 13.64; N, 16.76
Synonym:?PLX3397; PLX-3397; PLX 3397; CML-261; CML 261; CML261; FP-113; FP 113; FP113; Pexidartinib; Turalio
IUPAC/Chemical Name:?5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
InChi Key:?JGWRKYUXBBNENE-UHFFFAOYSA-N
InChi Code:?InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
SMILES Code:?FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
Appearance:?Yellow solid powder
Purity:?>98% (or refer to the Certificate of Analysis)
Shipping Condition:?Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition:?Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility:?Soluble in DMSO (20mg/ mL), not in water
Shelf Life:?>2 years if stored properly
Drug Formulation:?This drug may be formulated in DMSO
Stock Solution Storage:?0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code:?2934.99.9001