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H-5582
rec Leptin (mouse)
Synonym:
rec Obesity Factor (mouse), rec Obese Protein (mouse)
| [1061787-61-8] | ||
| Longterm storage temperature: | -20 ± 5 °C | ? |
16 kDa
Family Description:
Leptin, the product of the obese gene (ob), is a hormone secreted by adipocytes. Administration of recombinant mouse leptin in ob/ob mice - homozygous ob mutants suffering from obesity - corrected both overeating and obesity. Moreover leptin reduced the appetite and weight of mice with diet-induced obesity, and caused significant loss of body weight and fat content in lean mice.
For other Leptin fragments please inquire.
Family Literature:
Y.Zhang et al., Nature, 372, 425 (1994)
J.L.Halaas et al., Science, 269, 543 (1995)
J.D.McGarry, Curr. Biol., 5, 1342 (1995)
L.A.Campfield et al., Science, 269, 546 (1995)
M.A.Pelleymounter et al., Science, 269, 541 (1995)
R.V.Considine et al., N. Engl. J. Med., 334, 292 (1996)