GRM8 (Human) Recombinant Protein (Q01)
產品名稱: GRM8 (Human) Recombinant Protein (Q01)
英文名稱: GRM8 (Human) Recombinant Protein (Q01)
產品編號: H00002918-Q01
產品價格: 0
產品產地: 臺灣
品牌商標: Abnova
更新時間: null
使用范圍: null
亞諾法生技股份有限公司(Abnova)
- 聯系人 :
- 地址 : 臺灣臺北市內湖區洲子街 108 號 9 樓
- 郵編 : 11493
- 所在區域 : 臺灣
- 電話 : +886-920**1152 點擊查看
- 傳真 : 點擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human GRM8 partial ORF ( NP_000836, 486 a.a. - 575 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- KVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPII
- Theoretical MW (kDa):
- 35.64
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.

- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 2918
- GeneBank Accession#:
- NM_000845
- Protein Accession#:
- NP_000836
- Gene Name:
- GRM8
- Gene Alias:
- FLJ41058,GLUR8,GPRC1H,MGC126724,MGLUR8,mGlu8
- Gene Description:
- glutamate receptor, metabotropic 8
- Omim ID:
- 601116
- Gene Ontology:
- Hyperlink
- Gene Summary:
- L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000024506,glutamate metabotropic receptor 8
- Gene Pathway
- Related Disease
- Alcohol Withdrawal Delirium
- Alcohol Withdrawal Seizures
- Alcoholism
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Brain Ischemia
- Cardiovascular Diseases
- Cognition
- Colitis, Ulcerative
- Coronary Disease
- Crohn Disease
- Crohn's disease
- Genetic Predisposition to Disease
- Heroin Dependence
- Inflammatory Bowel Diseases
- Myocardial Infarction
- NARP
- Opioid-Related Disorders
- Schizophrenia
