CDKN1B/p27KIP1 Rabbit pAb (APR23310N)
產(chǎn)品名稱： CDKN1B/p27KIP1 Rabbit pAb (APR23310N)
英文名稱： CDKN1B/p27KIP1 Rabbit pAb (APR23310N)
產(chǎn)品編號(hào)： APR23310N
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 美國(guó)
品牌商標(biāo)： Leading Biology
更新時(shí)間： null
使用范圍：
生物谷
- 聯(lián)系人 : 請(qǐng)聯(lián)系郵箱
- 地址 : 上海市徐匯區(qū)光啟城辦公樓3樓
- 郵編 : 100176
- 所在區(qū)域 : 上海
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- 傳真 : 點(diǎn)擊查看
- 郵箱 : business@bioon.com
分子量：Calculated MW: 22kDa Observed MW: 27kDa 細(xì)胞定位：Cytoplasm, Endosome, Nucleus 稀釋方法：WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 總結(jié)：This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).