Anti-DDB1 Monoclonal Antibody
品牌：solarbio | 貨號：K001425M
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選擇規格
K001425M-50ul
solarbio
50ul
960.00元
K001425M-100ul
solarbio
100ul
1600.00元

英文名稱
Anti-DDB1 Monoclonal Antibody
別名
DDBA;UV-DDB1;XAP1;XPCE;XPE;XPE-BF
應用
WB
稀釋比例
WB 1:1000.
交叉反應
Human Mouse Rat Monkey
蛋白分子量
127kDa
Gene ID
1642
保存
Store at -20°C. Avoid freeze / thaw cycles.
儲存液
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法
Affinity purification
亞型
IgG2b
免疫原
Purified recombinant human DDB1 protein fragments expressed in E.coli.
性狀
液體
Public Immunogen Range
Purified recombinant human DDB1 protein fragments expressed in E.coli.
Subcellular Locations
Cytoplasm Nucleus
Swiss Prot
Q16531
克隆號
2D6-B5-E6
克隆類型
Monoclonal Antibody
背景資料
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit.This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage.Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas.However,it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit.In addition,Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.[provided by RefSeq,May 2012]