IR VIVO近紅外二區小動物活體成像系統
產品名稱： IR VIVO近紅外二區小動物活體成像系統
英文名稱：
產品編號： IR VIVO
產品價格： 0
產品產地： 加拿大
品牌商標： PHOTON ETC
更新時間： null
使用范圍： null
上海佰琺科學儀器有限公司
- 聯系人 :
- 地址 : 上海市徐匯區
- 郵編 :
- 所在區域 : 上海
- 電話 : 187****0416 點擊查看
- 傳真 : 點擊查看
- 郵箱 : yolanda@biotimestech.com
IR VIVOTM?近紅外二區小動物活體成像系統
? ? 目前常見的分子影像技術如X-射線成像、斷層掃描成像（CT）、磁共振成像（MRI）和超聲成像（US）被用于對疾病等的醫療診斷，但這些方法具有較差的空間分辨率及其無法實現動態實時監測等缺點。光學成像技術以其高靈敏度和高時空分辨率等優點，為微小腫瘤/轉移瘤及腫瘤相關血管的檢測和研究提供了一種新的無創檢測成像手段，在生物醫學和臨床診斷中發揮著重要作用。在過去幾年里，研究者們致力于研究近紅外第一窗口（700 nm~900 nm）的熒光成像，但是由于生物組織在這個波段范圍內有很強的吸收和散射，致使其信噪比和組織穿透深度都比較低。相對于NIR-I區成像，新一代的近紅外二區光學成像（NIR-II，1000-1700 nm）在成像靈敏度、穿透深度和空間分辨率方面有著顯著提高。因此，近年來，位于近紅外第二窗口（NIR-II，1000 nm~1700 nm）的材料得到了廣泛的關注，在這個波段，生物組織自身的吸收和散射弱，這樣就可以極大地提高成像質量和穿透深度。目前，一些無機材料如稀土下轉換納米顆粒、碳納米管、量子點以及少數有機染料能夠實現NIR-II的發射，但是它們的激發波長都位于近紅外第一窗口內。因此，開發激發波長和發射波長都位于NIR-II的材料成為目前生物成像的熱點。
? ? IR-VIVO是一款用于用于活體近紅外二區成像的高光譜成像系統。IR-VIVO使用可調諧濾波片和高光譜提供多光譜成像，成像范圍可從850nm到1620nm，分辨率可達到4nm，憑借高效率的濾波器和高速科研級SWIR相機，VIVO可以準確的獲得多個IR熒光譜，并可以實時成像，為涉及第二生物窗口檢測的應用提供了完美工具。近紅外二區（1000至1700 nm）中成像時，組織的散射減少，組織吸收和自發熒光最小。結果，與傳統的可見光或紅外光學成像（即400-1000 nm）相比，在這些波長下具有更好的圖像對比度，靈敏度和對組織的穿透深度。
NIR-II成像特性
- 高空間分辨率
- 高時間分辨率（實時動態）
- 非電離和非侵入性
- 良好的穿透深度（比傳統的可見光學系統大10倍）
應用領域：
? ? NIR-II成像增加的穿透深度和對比度，再加上快速的采集速度和微米級的空間分辨率，可以同時觀察通過完整顱骨的微脈管系統和血流。其他生物學應用包括化療藥物的藥代動力學以及肝臟和血液循環中的脂質定量。
? ? PHOTON ETC還開發了臨床前的二區成像紅外相機ZephIR?1.7，以滿足研究二區生物學窗口的研究人員的需求。
PUBLICATIONS
1.REAL TIME IN VIVO IMAGING IF ICG IN THE NIR-II?
with IR VIVO? Imaging system
? ? We sought to develop a near infrared II small animal imaging system which could provide real time images and videos of shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths would give optimal resolution for in vivo optical imaging due to the low tissue autofluorescence, scattering and absorption of light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate, hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.
2.INSIGHT FROM THE INDUSTRY - IR VIVO
USING PRE-CLINICAL IMAGING TO DETECT CANCER
By émilie Beaulieu-Ouellet, Application Scientist in Life Science
? ? In this interview, émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO? and its technology. Photon etc.’s IR VIVO? system is the first and only turnkey hyperspectral preclinical imager optimized for imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on the market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration depth imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of possibilities for fundamental and biopharmaceutical research.
1.REAL TIME IN VIVO IMAGING IF ICG IN THE NIR-II?
with IR VIVO? Imaging system
? ? We sought to develop a near infrared II small animal imaging system which could provide real time images and videos of shortwave IR (SWIR) fluorescent signals in vivo at wavelengths over 1000 nm. It was hypothesized that the SWIR wavelengths would give optimal resolution for in vivo optical imaging due to the low tissue autofluorescence, scattering and absorption of light at these wavelengths. The desired preclinical imaging system should enable measurement of heart rate, respiratory rate, hepatic function, hepatobiliary and intestinal function, blood flow and angiography in small animals.
2.INSIGHT FROM THE INDUSTRY - IR VIVO
USING PRE-CLINICAL IMAGING TO DETECT CANCER
By émilie Beaulieu-Ouellet, Application Scientist in Life Science
? ? In this interview, émilie Beaulieu Ouellet talks about the recently released and breakthrough imaging system: the IR VIVO? and its technology. Photon etc.’s IR VIVO? system is the first and only turnkey hyperspectral preclinical imager optimized for imaging in the second biological window of the near-infrared (NIR-II) / short-wavelength infrared (SWIR) range available on the market to our knowledge. NIR-II imaging will bring an unprecedented combination of fast, high resolution and penetration depth imaging at lower cost and to a broader community than current preclinical imaging techniques. Altogether, it will enable to resolve and track single biomedical targets or processes throughout small animals, thereby opening a new window of possibilities for fundamental and biopharmaceutical research.