IL-18 BP, Human
產(chǎn)品名稱： IL-18 BP, Human
英文名稱：
產(chǎn)品編號： CB055-1792
產(chǎn)品價格： 0
產(chǎn)品產(chǎn)地： 美國
品牌商標(biāo)： ExCell Bio
更新時間： null
使用范圍： null
上海吉泰依科賽生物科技有限公司
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Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.