Mepolizumab ( 美泊珠單抗 )
產(chǎn)品名稱(chēng)： Mepolizumab ( 美泊珠單抗 )
英文名稱(chēng)：
產(chǎn)品編號(hào)： FrdE00019
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 中國(guó)
品牌商標(biāo)： Frdbio
更新時(shí)間： 2023-08-15T17:03:56
使用范圍： 僅供科研使用
- 聯(lián)系人 : 趙經(jīng)理
- 地址 : 光谷國(guó)際B座1513
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- 所在區(qū)域 : 湖北省
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Product name:Mepolizumab (?美泊珠單抗?)
Catalog No. :?FrdE00019
MW:149000.00 Da
Description:Mepolizumab is a humanized IL-5 antagonist monoclonal antibody produced by recombinant DNA technology in Chinese hamster ovary cells.It has a molecular weight of approximately 149 kDa.It was approved by the FDA in November,2015 for the treatment of asthma under the brand name Nucala (marketed by GlaxoSmithKline).Mepolizumab has been investigated in the treatment of severe nasal polyposis,among numerous other conditions.Mepolizumab is an interleukin-5 antagonist (IgG1 kappa).IL-5 is the major cytokine responsible for the growth and differentiation, recruitment, activation,and survival of eosinophils.Mepolizumab binds to IL-5 with a dissociation constant of 100 pM,inhibiting the bioactivity of IL-5 by blocking its binding to the alpha chain of the IL-5 receptor complex expressed on the eosinophil cell surface.Inflammation is an important component in the pathogenesis of asthma. Multiple cell types (e.g., mast cells,eosinophils, neutrophils,macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) are involved in inflammation.Mepolizumab,by inhibiting IL-5 signaling, reduces the production and survival of eosinophils;however,the mechanism of mepolizumab action in asthma has not been definitively established.
Alternative names:Mepolizumab
Specificity target name;species:IL5[Homo sapiens]
Form:?Liquid
Receptor identification:IgG1-kappa
Storage:?Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 °C for frequent use. Store at -20 to -80 °C for twelve months from the date of receipt.
Purity:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note:?This product is for research use only,not for diagnostic or therapeutic use.