Anti-Dnmt3L mAb: ATTO 594 [S117-9]
產(chǎn)品名稱： Anti-Dnmt3L mAb: ATTO 594 [S117-9]
英文名稱： Dnmt3L Monoclonal Antibody: ATTO 594 [S117-9]
產(chǎn)品編號： SMC-341D-A594
產(chǎn)品價格： null
產(chǎn)品產(chǎn)地： 加拿大
品牌商標(biāo)： StressMarq
更新時間： null
使用范圍： WB, ICC, IP
StressMarq
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Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue (1-6). Studies show that DNMT3L regulates the activity of DNMT3A and DNMT3B and stimulates their catalytic activities (7). DNMT3L has specifically been linked to the process of carcinogenesis, thru its role in nuclear programming (8).