RNASEL monoclonal antibody, clone 2E9
產(chǎn)品名稱(chēng)： RNASEL monoclonal antibody, clone 2E9
英文名稱(chēng)： RNASEL monoclonal antibody, clone 2E9
產(chǎn)品編號(hào)： MAB2378
產(chǎn)品價(jià)格： null
產(chǎn)品產(chǎn)地： 臺(tái)灣
品牌商標(biāo)： Abnova
更新時(shí)間： null
使用范圍：
亞諾法生技股份有限公司（Abnova)
- 聯(lián)系人 :
- 地址 : 臺(tái)灣臺(tái)北市內(nèi)湖區(qū)洲子街 108 號(hào) 9 樓
- 郵編 : 11493
- 所在區(qū)域 : 臺(tái)灣
- 電話(huà) : +886-920**1152 點(diǎn)擊查看
- 傳真 : 點(diǎn)擊查看
- 郵箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant RNASEL.
- Immunogen:
- Recombinant protein corresponding to full length human RNASEL.
- Host:
- Mouse
- Reactivity:
- Human, Primates
- Specificity:
- This antibody is specific to human RNaseL.
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In PBS (0.1% sodium azide)
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western Blot (1:1000-1:4000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ.J Virol. 2007 Jun;81(11):5561-72. Epub 2007 Mar 7.
- 2.
- Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Gronberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J.Nat Genet. 2002 Feb;30(2):181-4. Epub 2002 Jan 22.
- 3.
- Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Wang L, Zhou A, Vasavada S, Dong B, Nie H, Church JM, Williams BR, Banerjee S, Silverman RH.Clin Cancer Res. 1995 Nov;1(11):1421-8.
- 4.
- 2-5A-dependent RNase molecules dimerize during activation by 2-5A.
Dong B, Silverman RH.J Biol Chem. 1995 Feb 24;270(8):4133-7.
- Applications
- Western Blot (Transfected lysate)
- Western blot analysis of RNASEL in transfected cells (0.1 ug) and Hey1B (100 ug), using RNASEL monoclonal antibody, clone 2E9 (Cat # MAB2378).
- Entrez GeneID:
- 6041
- Gene Name:
- RNASEL
- Gene Alias:
- DKFZp781D08126,MGC104972,MGC133329,PRCA1,RNS4
- Gene Description:
- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq
- Other Designations:
- 2',5'-oligoisoadenylate synthetase-dependent,OTTHUMP00000033148,interferon-induced 2-5A-dependent RNase,ribonuclease 4,ribonuclease L
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Biliary Tract Neoplasms
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Colorectal Neoplasms
- Diabetes Complications
- Disease Progression
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hepatitis C
- Inflammation
- Lung Neoplasms
- Metabolic Syndrome X
- Neoplasms
- Obesity
- Obesity